Summary:

My current research interests involve immune cell function in the central nervous system, specifically the retina. I am particularly interested in microglia, which are resident innate immune cells of the central nervous system. Current efforts employ the zebrafish model system and seek to understand the role of microglia in the development of the retina, how microglia respond to neuronal cell death, and how they may support or be detrimental to neuronal regeneration.

Minimum Classes:

General Biology
Cell Biology
Helpful but not required: Immunology, neuroscience

Projects:

Characterization of microglia in the zebrafish retina during development and/or regeneration following selective lesioning of zebrafish retina: Examine microglial cells in embryonic zebrafish retinas at various time points post-fertilization and/or during retinal regeneration. Techniques may include one or more of the following: work with zebrafish, tissue dissection and processing, tissue sectioning, live imaging on spinning disk confocal microscope, qPCR.

Effects of immune modulation on retinal regeneration in zebrafish: Experiments to evaluate how suppressing the immune response or over-activating the immune response affect the outcome of retinal regeneration following selective lesioning of zebrafish retina. Techniques will include one or more of the following: work with zebrafish, tissue dissection and processing, sectioning, immunohistochemistry, fluorescent microscopy on spinning disk confocal microscope, qPCR.

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