Summary: Mainali research group is mainly focused in the development and applications of state-of-the-art Electron Paramagnetic Resonance (EPR) techniques and methods to study the structure, dynamics and function of model and biological membrane in the systems that are relevant to human health and diseases.

Minimum classes: N/A


  1. Interaction of alpha-crystallin with cholesterol bilayer domains in cataract formation: A great deal of evidence suggests that the amount of membrane-bound alpha-crystallin increases with age and cataract progression. I hypothesized that the high cholesterol content and the formation of pure cholesterol bilayer domains decreases the binding of alpha-crystallin to lens membrane, which should protect against cataract development. These studies will provide alternative strategies for preventing and slowing the progression of cataract.
  2. Cholesterol membrane domains and cholesterol crystals in atherosclerosis: The major goal of this research is to understand the function of cholesterol, cholesterol bilayer domain and cholesterol crystals in the initiation of the atherosclerotic process. The findings of this research should indicate new potential strategies and targets for the therapy of this disease.

Major biophysical techniques used in the above research projects are electron paramagnetic resonance (EPR), atomic force microscopy (AFM), and differential scanning calorimetry (DSC).

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